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PREVENTING CANCER, SURVIVING CANCER: HOPE FOR THE FUTURE – BONE-MARROW TRANSPLANTS AND GENE THERAPY

Wednesday, February 16th, 2011
The trouble with current drug therapy for cancer is that these potent drugs cannot be given in unlimited doses — which, theoretically, could kill off all tumours — because they destroy not only cancerous cells but also normal cells, especially blood-manufacturing cells in the bone marrow.
A possible answer to this hurdle is the bone-marrow transplant. In this procedure, bone-marrow cells are temporarily removed and frozen. After drugs in high doses are used to kill cancer cells, the bone-marrow cells are replaced.
Human trials, using the procedure for women with advanced breast cancer, have shown promising results in the U.S. But the transplant is expensive, involves a long hospital stay, and carries an unacceptable mortality rate of 15 per cent.
Gene therapy is moving from the research lab to the clinic, and it promises new ways to prevent — and treat — cancer in the future.
Several plants — among them, the tobacco plant, chief engineer of lung cancer — are being genetically engineered to produce medical treatments for cancer. Scientists insert the human gene (for, say, a cancer of the female reproductive tract) into the plant, thereby stimulating it to produce quantities of antibodies to the cancer. These antibodies, numbering a million or more, are then harvested for potential use as anti-cancer drugs in humans.
Other approaches in gene therapy include inserting normal genes to correct abnormal ones; and drugs that combat the effects of abnormal genes.
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PREVENTING CANCER, SURVIVING CANCER: HOPE FOR THE FUTURE – BONE-MARROW TRANSPLANTS AND GENE THERAPYThe trouble with current drug therapy for cancer is that these potent drugs cannot be given in unlimited doses — which, theoretically, could kill off all tumours — because they destroy not only cancerous cells but also normal cells, especially blood-manufacturing cells in the bone marrow.A possible answer to this hurdle is the bone-marrow transplant. In this procedure, bone-marrow cells are temporarily removed and frozen. After drugs in high doses are used to kill cancer cells, the bone-marrow cells are replaced.Human trials, using the procedure for women with advanced breast cancer, have shown promising results in the U.S. But the transplant is expensive, involves a long hospital stay, and carries an unacceptable mortality rate of 15 per cent.Gene therapy is moving from the research lab to the clinic, and it promises new ways to prevent — and treat — cancer in the future.Several plants — among them, the tobacco plant, chief engineer of lung cancer — are being genetically engineered to produce medical treatments for cancer. Scientists insert the human gene (for, say, a cancer of the female reproductive tract) into the plant, thereby stimulating it to produce quantities of antibodies to the cancer. These antibodies, numbering a million or more, are then harvested for potential use as anti-cancer drugs in humans. Other approaches in gene therapy include inserting normal genes to correct abnormal ones; and drugs that combat the effects of abnormal genes.*73\332\2*

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