Archive for the 'Cancer' Category
THE BASICS FOR SAFE NON-TOXIC CLEANING SOLUTIONS (ALL-PURPOSE SPRAY CLEANER; FURNITURE POLISH; VINEGAR DEODORIZER)
Monday, May 23rd, 2011WHY IS IT SO DIFFICULT TO STUDY DIET AND CANCER?
Wednesday, January 26th, 2011WHY IS IT SO DIFFICULT TO STUDY DIET AND CANCER?Every attempt to unravel the relationship between diet and cancer runs up against a whole series of difficulties.• Diet is very complex. We have already made it clear how many different factors there are in the average diet. Not only is it always going to be difficult to work out which factors are important but we must recognize that they are not likely to act independently. A diet that is rich in something that causes cancer might not seem too bad if it is also rich in something which gives protection against cancer. Unravelling the interactions between these factors presents real problems.• It is difficult to measure diet accurately. Not only is there great variation in diet but people make a lot of mistakes in recalling their food intake over the previous days. In some studies as many as 50 per cent of people will be found to have made a mistake about important dietary elements when these are cross-checked against independent observations of what they have actually eaten. For some reason, fruit and vegetable content seems to be particularly vulnerable to errors of recall.• It is difficult to know the amount of a nutrient in any item eaten. For instance, if you have a steak, how much fat is there likely to be in it? This will vary from animal to animal and depends on the preparation and method by which it is cooked. Some of these variations are moderate for the minor constituents of diet. For instance, the variation in carotene, en important constituent of many vegetables, can be two- or threefold between different vegetables. Essentially the more orange a carrot is, the more carotene it contains. Two- or threefold variations may not be crucial hi working out the quantities of a substance in someone’s diet but other factors In the diet may vary several hundredfold. Selenium is an element which has been associated with a protective effect against cancers in some studies. The selenium content of a food will depend upon the selenium content of the soil upon which the vegetables were grown or the animals grazed.Selenium can vary between such low levels that animals are at risk of selenium deficiency through to such high levels that animals are at risk of selenium poisoning. The selenium content of meat may vary two hundredfold and, for most dietary histories, the source of a particular food may not be knows. It can be seen that dietary histories that are taken in an attempt to estimate selenium intake are not likely to be worthwhile and other approaches to this topic have had to be found.• Laboratory experiments are difficult to interpret. The impact of diet on cells grown in laboratory dishes is not easy to work out and if we observe the impact of changing the nutrient fluid in which the cells are suspended such observations will only give us weak clues as to what we might expect from any changes in exposure for these kinds of cells in a person. Observations on rats and mice which are fed on diets with differing contents of, for instance, fat or vitamins have given us some clues. However, the diets of small animals cannot accurately reflect what happens in people. Information from experiments may contribute a little piece to the jigsaw as we try to build the truth about the relationship between diet and cancer but they will never be capable of giving us clear answers.• Epidemiological studies are hard to perform on diet. Case control and cohort studies of the kind which we discussed earlier are difficult because it is hard to estimate exactly people’s exposure to different risks in the diet. Nevertheless, they can be done and they have been undertaken for many important dietary factors. The greatest difficulty for the epidemiologist is that he or she cannot easily do the intervention studies that may be most informative. Any intervention study can only be conducted with the consent of a very large number of people and those people then need to stick quite well to the rules within the study. Major change in diet is hard enough to achieve even for a compelling personal reason like obesity. It is that much more difficult for the sake of a scientific study. The individual people involved cannot be absolutely certain that the changes in the diet are going to benefit them. Smaller dietary changes like adding supplements in the form of capsules or tablets may be possible and it is in this area that most progress has been made.*55\194\4*